Didn't James Thurber write a book "The Wonderful O" ?

And halfway through the letter o disappears from the alphabet, so that "Ophelia Oliver couldn't go out of doors..."

A quick google search reveals that it was even made into a musical! http://alt.venus.co.uk/weed/music/salliterri/wondero.htm...never knew that, but somehow the cynic in me suspects that the book was better)