Au contraire, mon frere. The queen of mystery writers, Dorothy L Sayers, in The Documents in the Case, written with Robert Eustace, fashioned a plot that had the solution to a murder turn on the fact that the organic form of the poison which killed the victim had a lefthand twist but the synthetic form of the same compound had a righthand twist. A book I recommend very highly; it's one of my favorites. Written in the epistolary style and as notable for its literary qualities as for its ingenious plot. (No Lord Peter Wimsey.)