Not to forget the T-shirt with the slogan "Lefties have Rights Too".

Most Computer Mice, are symettrical, and even some of the fancy ones are sold in left hand versions. The buttons can be logically swapped if you so desire. Getting the scroll bars on the left of screens is more difficult, but with the new scrolling wheels on mice, that is not so much a problem.

Some left-handed guitarists have been known to play a right-handed guitar in a left-handed fashion (can't remember the famous example), but it gives a whole new sound from the direction of strike and some chord finguring differences.

But there is definitely an anti-lefty bias in words like sinister, cack-handed, and the like. Another minefield to avoid (if you have a feisty lefty sister-in-law like I have)