I really like the derivation of the word "execrate" - From Latin execrari (to curse), from ex- + sacrare (to consecrate). Ultimately from the Indo-European root sak- (to sanctify), which is also the source of other words such as saint, consecrate, sacred, execrable, and sacrilegious. Earliest documented use: 1561.

There are times when something which is not sacred or holy deserves to be detested, denounced, or cursed.