Regarding my comment on the pronounciation of ASCII, MaxQ ponders: "But of course. How else would one say it?

It's the question of a C before an I which should be prononuced as an S, giving us ass-see or ass-eye.

Another problem I run into when I am wearing my proofreader's hat is whether a pronounceable abbreviation is pronounced as a word or with its letters when the initial letter is one in which is pronounced with a vowel sound but represents a consonant sound, e.g., HID (Human Interface Device). I'll see that in an engineer's report as a HID or an HID, sometimes both ways in the same engineer's report. That means I have to track down a representative cross section of engineers to tell me whether it's pronounced [hid] or [aitch-eye-dee]