one is acceptable and another isn't
perhaps it depends on what "kind" of people adopt said drug?

definately. there are subsystems in any society. many religious groups frown on alcohol, (even wine) and some, prohibit caffine, (no cola, coffee or tea) and others employ drugs as part of their religious cerimonies.

teen agers, and others who want to test societal mores often experiment with proscribed 'drugs'.

and then there are people like rush limbaugh!