I think, Dr Bill's definition is a little older. Jackie's description of the usage is the way we would commonly do it these days. It's common for people to say, "I was devastated" when they hear very bad news. Harmful is more general. Detrimental suggests something that is likely to have bad effects. Common usage would be something like, "Smoking is detrimental to your health". Destructive would imply that there was some wide spread destruction as a result of the thing that is being described as destructive.