Cinci has a downtown, which is an appropriate name because it's down in a valley compared to the rest of the city. Then directly north across the boulevard that was once a canal lies riot central (Over the Rhine), certainly not uptown. Then north of that is, in succession, University of Cincinnati (home base), the zoo, and Xavier University.

So I guess Cinci doesn't have an uptown. I suppose there are areas that could be described as an uptown, but they have specific names. Mount Adams is a fairly high class village-like community to the east overlooking downtown. It's the home of the art museum, a contemporary theater and a nice park, but it's never called uptown.