In NY, down town and uptown are relitive terms.

i grew up in the bronx, and all of Mannhattan was 'downtown' midtown is from about 23rd to 59th street, downtown starts below Canal, (in between is the village, ie, greenwich village, or (NY) SoHo (south of Houston)

we all so have cross town, and "east side" (cultured, and rich), or "west side" intelectual, and upper middle class. with many, many exceptions!

Lower east side -- and alphabet city, Triceca, DUMBO (down under the manhattan bridge overpass-- a area that is both in manhattan and brooklyn, all residental-- residential areas all have neighborhood names-- and they have "identities" People move into them because they want to be associated with those identites. (London i think is the same.)

downtown and and midtown, are business area names. i work in civic center, the north end of Downtown. there is a full mile more of downtown south of where i work.. but i am almost a half mile south of Canal-- the beginning of downtown! Other downtown areas include the now defunct WTC, Wall Street, South Ferry, the Seaport, Bowling Green.