There are some wrinkles that cannot be ironed out. Years ago the comic strip "Dick Tracy" featured a villain named "Pruneface" whose face was a mass of wrinkles. The only condition I know of that could be responsible is rhagades, a dermatology lesion of late stages of an STD (acronym to spare the sensitive) with causative agent Treponema pallidum.
Maybe other participants can remember some of the other villains in the strip with interesting peculiarities.