Hmm, which of the two obvious senses would I choose to lose. Knowing sign language obviously eliminates the loss of sight as an option. But between losing speech and hearing, I think it might be too close to call. I'd probably lean towards losing speech and rely on my hands to do the talking.

And an aside about blindness and deafness that I see illustrated every single day. Helen Keller said "being blind may separate you from things... but being deaf separates you from people." Look around at how socialized many blind people are, and then check in on how the deaf are so isolated and oppressed that they have created what anthropologists call a completely different culture. It deserves some thought.