Around here, people say that someone "has a load on" if they're drunk.

In my opinion, the phrase seems more closely related to Baby's diapers than to drunkenness.

i agree, rapunzel! your comment brings to mind a card i received when one of my babies was born, which said something to the effect of "You know you're a redneck when you think the '12-14lbs' label on the diaper package refers to the load it can hold."

as for the original conversation, "pissed" would almost always mean angry around here, but it's not a very nice word to use. for drunkenness, we usually use "lit" or "plastered".