"And lastly, seated on some of the back benches, where they had
already taken up their positions for the evening, were divers
unmarried ladies past their grand climacteric, who, not dancing
because there were no partners for them, and not playing cards
lest they should be set down as irretrievably single, were in the
favourable situation of being able to abuse everybody without
reflecting on themselves. "

Climacteric
(a.) Relating to a climacteric; critical.
(n.) A period in human life in which some great change is supposed to take place in the constitution. The critical periods are thought by some to be the years produced by multiplying 7 into the odd numbers 3, 5, 7, and 9; to which others add the 81st year.
(n.) Any critical period.

So it's not just result of failure to secrete homones.