What? its one of the easiest systems in the world..
Since 99% Streets run east/west, and 99% of Avenues run north/south, (nominally!) 30th street and 6th Avenue is a very easy place to find..and to get from there to 36th Street and 5th Avenue, is clearly 1 Avenue away (1 block) and 6 streets-- if you were uncertain.. just head in any direction.. if you go the wrong way you will be at 7th Avenue and 30th, or 6th Avenue and 29th.. but you will have the information you need to get to the right place in 1 block!

long time NY's know which way the traffic flows on most streets, and even in a strange neighborhood, can quickly figure out which way is Up (north) or down(south) The Empire state building still acts as landmark too, (the great southern landmarks are gone.. i am about 2 miles away from Empire state building, but i can see it from the street, one block away.