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OP Dear wofahulicodoc: I saw an article about kringles in one of my magazines this afternoon, but have to admit I had trouble following the discussion. Here is something similar from Internet:
Abstract.. HGF/SF and HGFl/MSP define a novel growth factor family whose members share the domain structure and the proteolytic process of activation of the blood proteinase precursor plasminogen. The amino acid and RNA sequences of HGF/SF and HGFl/MSP, the intron-exon organization of their genes and the predicted 3D structure of individual domains indicate that HGF/SF and HGFl/MSP evolved along with plasminogen and other members of the kringle–serine proteinase (KSP) superfamily from an ancestral gene that contained a single copy of the kringle domain, a serine proteinase domain and anmactivation peptide connecting the two domains. A series of intragenic duplications of the kringle domain, gene duplications, exon shuffling and deletions is responsible for the genes currently present in mammals, avians and amphibians. Plasminogen, HGF/SF and HGFl/MSP represent paradigmatic examples of the modern, multi-domain proteins typically associated with vertebrate organisms and illustrate a novel evolutionary pathway that led to the emergence of molecules with growth regulatory activity from proteolytic enzymes.
There are also Danish pastries called "kringles". I would rather be involved with those than the stuff in the paragraph above, which I cheerfully admit is Greek to me.
Entire Thread Subject Posted By Posted Kris Kringle wwh 01/19/02 09:25 PM Re: Kris Kringle wwh 01/20/02 02:46 PM Re: Kris Kringle Jackie 01/20/02 05:12 PM Re: Kris Kringle wwh 01/20/02 06:50 PM Re: Kris Kringle Wordwind 01/20/02 09:09 PM Re: Gwilliam Faldage 01/21/02 11:14 AM End of the line wofahulicodoc 01/21/02 12:56 AM Re: End of the line wwh 01/21/02 01:23 AM Re: End of the line doc_comfort 01/21/02 07:01 AM
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