has anyone ever heard an interjection such as given in the subject line? (I found evidence of a cartoon titled 'ratzafratz', but that doesn't sound quite right to me (and it's about mall rats, from 2007 - this word goes back much further..)

The sound Muttley used to make when he was swearing used to sound an awful lot like that. Here's a sample:

http://www.youtube.com/watch?v=yj3DBcpfMNQ

It sounds familiar, either from a book I read; I am thinking a childs book to one of my grand/babies, or a word spoken by my late grandmere. She was German.

I think you're right about a cartoon connection - which could also explain the subsequent ratzafratz.

I don't recall seeing Muttley, but Hanna-Barbera churned out a lot of cartoons that I did see: Huckleberry Hound, Quick Draw McGraw, Loopy De Loop, The Flintstones, Yogi Bear, Top Cat.. - and the voicing got passed around promiscuously.

I have used a variant of that for decades; probably a bit closer to "rezzafrazz," spoken low in the throat like a growl, to express mild annoyance or disappointment. Yes, Muttley is the likely source. I believe those cartoons first appeared when I was in college, where I found them to be a source of intellectual stimulation.

Peter

Oh I love Wacky Races! (That is the Muttley you refer to yes?) Always my favourite character...along with that 'cat' in The Flintstones...how I wish they were still broadcast!

Yes, "Wacky Races." I think they appeared in others, but I don't recall for sure, maybe "The Perils of Penelope Pitstop."

Gosh a mickle dickle pickle dog my cats and rowrbazzle.

Faldo

Also this out of the can in 1970

Ratz off to the mall

from the OP> (I found evidence of a cartoon titled 'ratzafratz', but that doesn't sound quite right to me (and it's about mall rats, from 2007 - this word goes back much further..)

note date; but 1970??

of course, you are right
the cartoon is an example of 'play on that word'